![]() ![]() This, in turn, triggers the release of inflammatory chemicals called cytokines and metalloproteinase that break down a structural protein called collagen, causing tissues to thin and form ulcers.Whenever cells are damaged by chemotherapy or radiation, they release unstable atoms called free radicals.Treatment-induced oral mucositis is the result of the following processes: Other chemotherapy drugs can do the same. Oral mucositis is an especially common occurrence when exposed to the chemotherapy drugs 5-fluorouracil (5-FU) or Evomela (melphalan).
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